Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia
TS Kern, RL Engerman - Archives of ophthalmology, 1996 - jamanetwork.com
Objective: To isolate microvessels from cerebral cortex of dogs with alloxan-induced
diabetes and dogs with experimental galactosemia to compare the prevalence of
microvascular lesions in cerebral cortex with that in retina. Methods: Microvessels were
isolated from cerebral cortex of experimental animals using a sieving method, and
compared with the retinal vasculature isolated from the same animals using the trypsin
digestion method. Results: Dogs with diabetes or experimental galactosemia of 5 years' …
diabetes and dogs with experimental galactosemia to compare the prevalence of
microvascular lesions in cerebral cortex with that in retina. Methods: Microvessels were
isolated from cerebral cortex of experimental animals using a sieving method, and
compared with the retinal vasculature isolated from the same animals using the trypsin
digestion method. Results: Dogs with diabetes or experimental galactosemia of 5 years' …