[HTML][HTML] Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R
OJ Hamming, L Kang, A Svensson, JL Karlsen… - Journal of Biological …, 2012 - ASBMB
IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune
responses. It signals through a heterodimeric receptor complex consisting of the IL-21
receptor (IL-21R) and the common γ-chain. A hallmark of the class I cytokine receptors is the
class I cytokine receptor signature motif (WSXWS). The exact role of this motif has not been
determined yet; however, it has been implicated in diverse functions, including ligand
binding, receptor internalization, proper folding, and export, as well as signal transduction …
responses. It signals through a heterodimeric receptor complex consisting of the IL-21
receptor (IL-21R) and the common γ-chain. A hallmark of the class I cytokine receptors is the
class I cytokine receptor signature motif (WSXWS). The exact role of this motif has not been
determined yet; however, it has been implicated in diverse functions, including ligand
binding, receptor internalization, proper folding, and export, as well as signal transduction …