[HTML][HTML] Akt enhances Mdm2-mediated ubiquitination and degradation of p53
Y Ogawara, S Kishishita, T Obata, Y Isazawa… - Journal of Biological …, 2002 - ASBMB
p53 plays a key role in DNA damage-induced apoptosis. Recent studies have reported that
the phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and
apoptosis, although the underlying mechanisms have yet to be determined. Mdm2, a
ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as
a good substrate for Akt. In this study, we find that expression of Akt reduces the protein
levels of p53, at least in part by enhancing the degradation of p53. Both Akt expression and …
the phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and
apoptosis, although the underlying mechanisms have yet to be determined. Mdm2, a
ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as
a good substrate for Akt. In this study, we find that expression of Akt reduces the protein
levels of p53, at least in part by enhancing the degradation of p53. Both Akt expression and …