Background RNA-directed regulation of epigenetic processes has recently emerged as an
important feature of mammalian differentiation and development. Perturbation of this
regulatory system in the brain may contribute to the development of neuropsychiatric
disorders. Methods RNA sequencing was used to identify changes in the experience-
dependent expression of long noncoding RNAs (lncRNAs) within the medial prefrontal
cortex of adult mice. Transcripts were validated by real-time quantitative polymerase chain …