Brief exposure to copper activates lysosomal exocytosis
K Peña, J Coblenz, K Kiselyov - Cell Calcium, 2015 - Elsevier
Copper (Cu) is essential mineral, but its toxicity necessitates existence of powerful
machinery responsible for the extraction of excess Cu from the cell. Cu exposure was
recently shown to induce the translocation of Cu pump ATP7B to the lysosomes followed by
lysosomal exocytosis. Here we sought to investigate the mechanisms underlying the effect of
Cu on lysosomal exocytosis. We found that brief exposure to Cu activates lysosomal
exocytosis, which was measured as a release of the lysosomal digestive enzyme β …
machinery responsible for the extraction of excess Cu from the cell. Cu exposure was
recently shown to induce the translocation of Cu pump ATP7B to the lysosomes followed by
lysosomal exocytosis. Here we sought to investigate the mechanisms underlying the effect of
Cu on lysosomal exocytosis. We found that brief exposure to Cu activates lysosomal
exocytosis, which was measured as a release of the lysosomal digestive enzyme β …