Notch signaling: control of cell communication and cell fate

EC Lai - 2004 - journals.biologists.com
2004journals.biologists.com
Notch is a transmembrane receptor that mediates local cell-cell communication and
coordinates a signaling cascade present in all animal species studied to date. Notch
signaling is used widely to determine cell fates and to regulate pattern formation; its
dysfunction results in a tremendous variety of developmental defects and adult pathologies.
This primer describes the mechanism of Notch signal transduction and how it is used to
control the formation of biological patterns.
Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.
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