The role of Notch in tumorigenesis: oncogene or tumour suppressor?
F Radtke, K Raj - Nature Reviews Cancer, 2003 - nature.com
F Radtke, K Raj
Nature Reviews Cancer, 2003•nature.comNotch signalling participates in the development of multicellular organisms by maintaining
the self-renewal potential of some tissues and inducing the differentiation of others.
Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the
notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting
evidence that Notch signalling is not exclusively oncogenic. It can instead function as a
tumour suppressor.
the self-renewal potential of some tissues and inducing the differentiation of others.
Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the
notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting
evidence that Notch signalling is not exclusively oncogenic. It can instead function as a
tumour suppressor.
Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
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