The influence of stress and glucocorticoids on neuronal pathology has been demonstrated
in animal and clinical studies. It has been proposed that stress-induced changes in the
hippocampus may be central to the development of depression in genetically vulnerable
individuals. New evidence implicates the prefrontal cortex (PFC) in addition to the
hippocampus as a site of neuropathology in depression. The PFC may be involved in stress-
mediated neurotoxicity because stress alters PFC functions and glucocorticoid receptors, the …