Soluble fms-like tyrosine kinase 1 (sFlt1), a circulating antiangiogenic protein, is elevated in
kidney diseases and contributes to the development of preeclampsia. Hydrogen sulfide is a
vasorelaxant and proangiogenic gas with therapeutic potential in several diseases.
Therefore, we evaluated the potential therapeutic effect and mechanisms of action of
hydrogen sulfide in an animal model of sFlt1-induced hypertension, proteinuria, and
glomerular endotheliosis created by adenovirus-mediated overexpression of sFlt1 in …