[HTML][HTML] Association of genetic polymorphisms on vascular endothelial growth factor and its receptor genes with susceptibility to coronary heart disease

L Li, Y Pan, L Dai, B Liu, D Zhang - Medical science monitor …, 2016 - ncbi.nlm.nih.gov
L Li, Y Pan, L Dai, B Liu, D Zhang
Medical science monitor: international medical journal of experimental …, 2016ncbi.nlm.nih.gov
Background Coronary heart disease (CHD) is a cardiovascular disease characterized by
high morbidity and mortality. Vascular endothelial growth factor (VEGF) and its receptor,
named kinase insert domain-containing receptor (KDR, or VEGFR2), which are involved
with angiogenesis and vascular repair, could partly contribute to the development of CHD.
The aim of this study, therefore, was to investigate the potential correlations between genetic
polymorphisms on VEGF and KDR and susceptibility to CHD, and the integrative role of …
Abstract
Background
Coronary heart disease (CHD) is a cardiovascular disease characterized by high morbidity and mortality. Vascular endothelial growth factor (VEGF) and its receptor, named kinase insert domain-containing receptor (KDR, or VEGFR2), which are involved with angiogenesis and vascular repair, could partly contribute to the development of CHD. The aim of this study, therefore, was to investigate the potential correlations between genetic polymorphisms on VEGF and KDR and susceptibility to CHD, and the integrative role of SNPs combined on susceptibility to CHD were also studied.
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