AP-1: a double-edged sword in tumorigenesis
R Eferl, EF Wagner - Nature Reviews Cancer, 2003 - nature.com
R Eferl, EF Wagner
Nature Reviews Cancer, 2003•nature.comThe AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but
recent studies have challenged this view—some AP-1 proteins, such as JUNB and c-FOS,
have been shown to have tumour-suppressor activity. Here, we focus on the JUN and FOS
proteins and aim to offer a new perspective on the molecular mechanisms that regulate the
oncogenic and anti-oncogenic effects of AP-1 in tumour development.
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but
recent studies have challenged this view—some AP-1 proteins, such as JUNB and c-FOS,
have been shown to have tumour-suppressor activity. Here, we focus on the JUN and FOS
proteins and aim to offer a new perspective on the molecular mechanisms that regulate the
oncogenic and anti-oncogenic effects of AP-1 in tumour development.
Abstract
The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS, ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but recent studies have challenged this view — some AP-1 proteins, such as JUNB and c-FOS, have been shown to have tumour-suppressor activity. Here, we focus on the JUN and FOS proteins and aim to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.
nature.com