[HTML][HTML] Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling
M Mori - The Journal of nutrition, 2007 - Elsevier
Nitric oxide (NO) is synthesized from arginine and O 2 by NO synthase (NOS). Citrulline
formed as a by-product of the NOS reaction can be recycled to arginine by argininosuccinate
synthetase (AS) and argininosuccinate lyase (AL). We found that AS and sometimes AL are
coinduced with inducible NOS (iNOS) in various cells. In these cells, NO was synthesized
from citrulline (via arginine) as well as from arginine, indicating operation of the citrulline-NO
cycle. On the other hand, we found that arginase isoforms (types I and II) are coinduced with …
formed as a by-product of the NOS reaction can be recycled to arginine by argininosuccinate
synthetase (AS) and argininosuccinate lyase (AL). We found that AS and sometimes AL are
coinduced with inducible NOS (iNOS) in various cells. In these cells, NO was synthesized
from citrulline (via arginine) as well as from arginine, indicating operation of the citrulline-NO
cycle. On the other hand, we found that arginase isoforms (types I and II) are coinduced with …