Genetic polymorphisms in arginase I and II and childhood asthma and atopy
H Li, I Romieu, JJ Sienra-Monge… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: A recent microarray study implicated arginase I (ARG1) and arginase II
(ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES: To examine
the association between genetic variation in ARG1 and ARG2 and childhood asthma and
atopy risk. METHODS: We enrolled 433 case-parent triads, consisting of patients with
asthma 4 to 17 years old and their biologic parents, from the allergy clinic of a public hospital
in Mexico City between 1998 and 2003. Atopy to 24 aeroallergens was determined by skin …
(ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES: To examine
the association between genetic variation in ARG1 and ARG2 and childhood asthma and
atopy risk. METHODS: We enrolled 433 case-parent triads, consisting of patients with
asthma 4 to 17 years old and their biologic parents, from the allergy clinic of a public hospital
in Mexico City between 1998 and 2003. Atopy to 24 aeroallergens was determined by skin …