Arginine, a semiessential or conditionally essential amino acid in humans, is one of the most
metabolically versatile amino acids and serves as a precursor for the synthesis of urea, nitric
oxide, polyamines, proline, glutamate, creatine, and agmatine. Arginine is metabolized
through a complex and highly regulated set of pathways that remain incompletely
understood at both the whole-body and the cellular levels. Adding to the metabolic
complexity is the fact that limited arginine availability can selectively affect the expression of …