Type 2 innate lymphoid cells in induced sputum from children with severe asthma
P Nagakumar, L Denney, L Fleming, A Bush… - Journal of Allergy and …, 2016 - jacionline.org
To the Editor: Innate lymphoid cells (ILCs) are characterized by their lymphoid morphology
and absence of lymphocyte lineage surface markers. 1 Group 2 ILCs (ILC2s) expressing
CD127 and CRTH2 are induced by the epithelial cytokines IL-33 and IL-25 and are
implicated in the pathogenesis of allergic airways disease in murine models. ILC2s have
been identified in cord blood, 2 tonsils, and nasal polyps from patients with chronic
rhinoosinusitis 3 and in peripheral blood and bronchoalveolar lavage (BAL) from adults with …
and absence of lymphocyte lineage surface markers. 1 Group 2 ILCs (ILC2s) expressing
CD127 and CRTH2 are induced by the epithelial cytokines IL-33 and IL-25 and are
implicated in the pathogenesis of allergic airways disease in murine models. ILC2s have
been identified in cord blood, 2 tonsils, and nasal polyps from patients with chronic
rhinoosinusitis 3 and in peripheral blood and bronchoalveolar lavage (BAL) from adults with …