IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma
S Saglani, S Lui, N Ullmann, GA Campbell… - Journal of allergy and …, 2013 - Elsevier
Background TH 2 cytokines are not responsible for the ongoing symptoms and pathology in
children with severe therapy-resistant asthma (STRA). IL-33 induces airway
hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown.
Objective We sought to investigate the relationship between IL-33 and airway remodeling in
pediatric patients with STRA. Methods IL-33 levels were quantified in neonatal mice given
inhaled house dust mite (HDM), and the effect of blocking IL-13 on remodeling and IL-33 …
children with severe therapy-resistant asthma (STRA). IL-33 induces airway
hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown.
Objective We sought to investigate the relationship between IL-33 and airway remodeling in
pediatric patients with STRA. Methods IL-33 levels were quantified in neonatal mice given
inhaled house dust mite (HDM), and the effect of blocking IL-13 on remodeling and IL-33 …