A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
A Bitsch, T Kuhlmann, C Stadelmann… - Annals of Neurology …, 2001 - Wiley Online Library
A Bitsch, T Kuhlmann, C Stadelmann, H Lassmann, C Lucchinetti, W Brück
Annals of Neurology: Official Journal of the American Neurological …, 2001•Wiley Online LibrarySevere tissue destruction is the presumed histopathological correlate of hypointense
multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity
over time with initial histopathological features in 14 biopsied MS lesions. The extent of
hypointensity increased in initially demyelinated plaques and decreased in remyelinating
lesions. The initial axonal loss determined the increase of hypointensity over time. In
conclusion, both axonal loss and demyelinating activity determine the evolution of …
multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity
over time with initial histopathological features in 14 biopsied MS lesions. The extent of
hypointensity increased in initially demyelinated plaques and decreased in remyelinating
lesions. The initial axonal loss determined the increase of hypointensity over time. In
conclusion, both axonal loss and demyelinating activity determine the evolution of …
Abstract
Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.
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