[HTML][HTML] Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers
SA Stacker, K Stenvers, C Caesar, A Vitali… - Journal of Biological …, 1999 - ASBMB
Vascular endothelial growth factor-D (VEGF-D) binds and activates the endothelial cell
tyrosine kinase receptors VEGF receptor-2 (VEGFR-2) and VEGF receptor-3 (VEGFR-3), is
mitogenic for endothelial cells, and shares structural homology and receptor specificity with
VEGF-C. The primary translation product of VEGF-D has long N-and C-terminal polypeptide
extensions in addition to a central VEGF homology domain (VHD). The VHD of VEGF-D is
sufficient to bind and activate VEGFR-2 and VEGFR-3. Here we report that VEGF-D is …
tyrosine kinase receptors VEGF receptor-2 (VEGFR-2) and VEGF receptor-3 (VEGFR-3), is
mitogenic for endothelial cells, and shares structural homology and receptor specificity with
VEGF-C. The primary translation product of VEGF-D has long N-and C-terminal polypeptide
extensions in addition to a central VEGF homology domain (VHD). The VHD of VEGF-D is
sufficient to bind and activate VEGFR-2 and VEGFR-3. Here we report that VEGF-D is …