Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system
S Letendre, J Marquie-Beck, E Capparelli… - Archives of …, 2008 - jamanetwork.com
Objective To evaluate whether penetration of a combination regimen into the central
nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is
associated with lower cerebrospinal fluid (CSF) viral load. Design Data were analyzed from
467 participants who were human immunodeficiency virus (HIV) seropositive and who
reported antiretroviral (ARV) drug use. Individual ARV drugs were assigned a penetration
rank of 0 (low), 0.5 (intermediate), or 1 (high) based on their chemical properties …
nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is
associated with lower cerebrospinal fluid (CSF) viral load. Design Data were analyzed from
467 participants who were human immunodeficiency virus (HIV) seropositive and who
reported antiretroviral (ARV) drug use. Individual ARV drugs were assigned a penetration
rank of 0 (low), 0.5 (intermediate), or 1 (high) based on their chemical properties …