Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques
Q Dang, S Whitted, RM Goeken, JM Brenchley… - Journal of …, 2012 - Am Soc Microbiol
Q Dang, S Whitted, RM Goeken, JM Brenchley, K Matsuda, CR Brown, BAP Lafont…
Journal of virology, 2012•Am Soc MicrobiolSimian immunodeficiency virus (SIV) infection of macaques can result in central nervous
system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated
with brain-derived virus from animals with SIV encephalitis. Over half of the macaques
developed SIV-induced neurologic disease. Elevated levels of systemic immune activation
were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma
viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated
with brain-derived virus from animals with SIV encephalitis. Over half of the macaques
developed SIV-induced neurologic disease. Elevated levels of systemic immune activation
were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma
viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
Abstract
Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
American Society for Microbiology