Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man
NW Morrell, KS Nijran, T Biggs, WA Seed - Respiration physiology, 1995 - Elsevier
Acute hypoxic pulmonary vasoconstriction has an established role in the preservation of
ventilation-perfusion balance. To further characterize this homeostatic response in man we
have attempted to measure both the time course and magnitude of blood flow diversion from
single hypoxic lobes. Lobar hypoxia (mean PO2 38±1.5 (SEM) mmHg, mean PCO2
39.9±0.9 mmHg) was induced by inflating catheter-tip balloons in left upper lobe bronchi
during fibreoptic bronchoscopy under local anaesthesia in 8 normal subjects. An index of …
ventilation-perfusion balance. To further characterize this homeostatic response in man we
have attempted to measure both the time course and magnitude of blood flow diversion from
single hypoxic lobes. Lobar hypoxia (mean PO2 38±1.5 (SEM) mmHg, mean PCO2
39.9±0.9 mmHg) was induced by inflating catheter-tip balloons in left upper lobe bronchi
during fibreoptic bronchoscopy under local anaesthesia in 8 normal subjects. An index of …