Expanding chemical biology of 2-oxoglutarate oxygenases
C Loenarz, CJ Schofield - Nature chemical biology, 2008 - nature.com
C Loenarz, CJ Schofield
Nature chemical biology, 2008•nature.comBeyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid
metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent
oxygenases in histone and nucleic acid demethylation and in signaling protein
hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone
modifications has some analogy with their role in enabling structural diversity in secondary
metabolism.
metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent
oxygenases in histone and nucleic acid demethylation and in signaling protein
hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone
modifications has some analogy with their role in enabling structural diversity in secondary
metabolism.
Abstract
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
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