Immune mechanisms of HIV control

LA Chakrabarti, V Simon - Current opinion in immunology, 2010 - Elsevier
LA Chakrabarti, V Simon
Current opinion in immunology, 2010Elsevier
HIV-1 can be contained by the immune system, as demonstrated by the existence of rare
individuals who spontaneously control HIV-1 replication in the absence of antiretroviral
therapy. Emerging evidence points to the importance of a very active cellular immune
response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV
restriction factors, the presence of protective MHC class I alleles, and the development of a
high avidity T-cell response may all cooperate in limiting HIV replication at an early stage …
HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.
Elsevier