[HTML][HTML] MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
CF Wong, RL Tellam - Journal of Biological Chemistry, 2008 - ASBMB
MicroRNA (miRNA) are important regulators of many bio× logical processes, but the targets
for most miRNA are still poorly defined. In this study, we profiled the expression of miRNA
during myogenesis, from proliferating myoblasts through to terminally differentiated
myotubes. Microarray results identified six significantly differentially expressed miRNA that
were more than 2-fold different in myotubes. From this list, miRNA-26a (miR-26a), an up-
regulated miRNA, was further examined. Overexpression of miR-26a in murine myogenic …
for most miRNA are still poorly defined. In this study, we profiled the expression of miRNA
during myogenesis, from proliferating myoblasts through to terminally differentiated
myotubes. Microarray results identified six significantly differentially expressed miRNA that
were more than 2-fold different in myotubes. From this list, miRNA-26a (miR-26a), an up-
regulated miRNA, was further examined. Overexpression of miR-26a in murine myogenic …