[HTML][HTML] Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients

P Dmitriev, L Stankevicins, E Ansseau, A Petrov… - Journal of Biological …, 2013 - ASBMB
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant hereditary
neuromuscular disorder linked to the deletion of an integral number of 3.3-kb-long
macrosatellite repeats (D4Z4) within the subtelomeric region of chromosome 4q. Most genes
identified in this region are overexpressed in FSHD myoblasts, including the double
homeobox genes DUX4 and DUX4c. We have carried out a simultaneous miRNome/
transcriptome analysis of FSHD and control primary myoblasts. Of 365 microRNAs (miRNAs) …