[HTML][HTML] A metabolic shift toward pentose phosphate pathway is necessary for amyloid fibril-and phorbol 12-myristate 13-acetate-induced neutrophil extracellular trap …
EP Azevedo, NC Rochael, AB Guimarães-Costa… - Journal of Biological …, 2015 - ASBMB
Neutrophils are the main defense cells of the innate immune system. Upon stimulation,
neutrophils release their chromosomal DNA to trap and kill microorganisms and inhibit their
dissemination. These chromatin traps are termed neutrophil extracellular traps (NETs) and
are decorated with granular and cytoplasm proteins. NET release can be induced by several
microorganism membrane components, phorbol 12-myristate 13-acetate as well as by
amyloid fibrils, insoluble proteinaceous molecules associated with more than 40 different …
neutrophils release their chromosomal DNA to trap and kill microorganisms and inhibit their
dissemination. These chromatin traps are termed neutrophil extracellular traps (NETs) and
are decorated with granular and cytoplasm proteins. NET release can be induced by several
microorganism membrane components, phorbol 12-myristate 13-acetate as well as by
amyloid fibrils, insoluble proteinaceous molecules associated with more than 40 different …