[HTML][HTML] The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

GM Delgoffe, KN Pollizzi, AT Waickman… - Nature …, 2011 - nature.com
GM Delgoffe, KN Pollizzi, AT Waickman, E Heikamp, DJ Meyers, MR Horton, B Xiao…
Nature immunology, 2011nature.com
The kinase mTOR has emerged as an important regulator of the differentiation of helper T
cells. Here we demonstrate that differentiation into the TH1 and TH17 subsets of helper T
cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was
dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate TH1 and
TH17 responses in vitro and in vivo and did not induce classical experimental autoimmune
encephalomyelitis (EAE). However, they retained their ability to become TH2 cells …
Abstract
The kinase mTOR has emerged as an important regulator of the differentiation of helper T cells. Here we demonstrate that differentiation into the TH1 and TH17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate TH1 and TH17 responses in vitro and in vivo and did not induce classical experimental autoimmune encephalomyelitis (EAE). However, they retained their ability to become TH2 cells. Alternatively, when mTORC2 signaling was deleted from T cells, they failed to generate TH2 cells in vitro and in vivo but preserved their ability to become TH1 and TH17 cells. Our data identify mechanisms by which two distinct signaling pathways downstream of mTOR regulate helper cell fate in different ways. These findings define a previously unknown paradigm that links T cell differentiation with selective metabolic signaling pathways.
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