[HTML][HTML] Specificity requirements for human telomere protein interaction with telomerase holoenzyme
AN Sexton, DT Youmans, K Collins - Journal of Biological Chemistry, 2012 - ASBMB
Human telomeres are maintained by the enzyme telomerase, which uses a template within
its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to
accomplish the synthesis of single-stranded DNA repeats. Many questions remain
unresolved about the cellular regulation of telomerase subunits and the fully assembled
telomerase holoenzyme, including the basis for the specificity of binding and acting on
telomeres. Previous studies have revealed that the telomere protein TPP1 is necessary for …
its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to
accomplish the synthesis of single-stranded DNA repeats. Many questions remain
unresolved about the cellular regulation of telomerase subunits and the fully assembled
telomerase holoenzyme, including the basis for the specificity of binding and acting on
telomeres. Previous studies have revealed that the telomere protein TPP1 is necessary for …