NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma
TO Makinde, R Steininger, DK Agrawal - Experimental and molecular …, 2013 - Elsevier
PURPOSE: Neuropeptide Y (NPY) level is elevated in allergic asthmatic airways and
activation of NPY receptor-1 (NPY-Y1) on antigen‐presenting cells (APCs) is essential for T
cell priming. Paradoxically, NPY-Y1 modulates hyper-responsiveness in T cells, suggesting
a bimodal role for NPY in APCs and T cells. Therefore, determination of the temporal and
spatial expression pattern of NPY and its receptors in asthmatic airways is essential to
further understand the role of NPY in allergic asthma. METHODS: Lungs were isolated from …
activation of NPY receptor-1 (NPY-Y1) on antigen‐presenting cells (APCs) is essential for T
cell priming. Paradoxically, NPY-Y1 modulates hyper-responsiveness in T cells, suggesting
a bimodal role for NPY in APCs and T cells. Therefore, determination of the temporal and
spatial expression pattern of NPY and its receptors in asthmatic airways is essential to
further understand the role of NPY in allergic asthma. METHODS: Lungs were isolated from …