[HTML][HTML] Signaling of human ciliary neurotrophic factor (CNTF) revisited: the interleukin-6 receptor can serve as an α-receptor for CNTF
B Schuster, M Kovaleva, Y Sun, P Regenhard… - Journal of Biological …, 2003 - ASBMB
Human ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that exerts a
neuroprotective effect in multiple sclerosis and amyotrophic lateral sclerosis. Clinical
application of human CNTF, however, was prevented by high toxicity at higher dosages.
Human CNTF elicits cellular responses by induction of a receptor complex consisting of the
CNTF α-receptor (CNTFR), which is not involved in signal transduction, and the β-receptors
gp130 and leukemia inhibitory factor receptor (LIFR). Previous studies with rat CNTF …
neuroprotective effect in multiple sclerosis and amyotrophic lateral sclerosis. Clinical
application of human CNTF, however, was prevented by high toxicity at higher dosages.
Human CNTF elicits cellular responses by induction of a receptor complex consisting of the
CNTF α-receptor (CNTFR), which is not involved in signal transduction, and the β-receptors
gp130 and leukemia inhibitory factor receptor (LIFR). Previous studies with rat CNTF …