Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies
S Pasquin, M Sharma, JF Gauchat - Cytokine & growth factor reviews, 2015 - Elsevier
Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine
family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe
phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of
this cytokine family play key, non-redundant roles during development. Accordingly, three
decades of research has revealed potent and promising trophic and regulatory activities of
CNTF in neurons, oligodendrocytes, muscle cells, bone cells, adipocytes and retinal cells …
family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe
phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of
this cytokine family play key, non-redundant roles during development. Accordingly, three
decades of research has revealed potent and promising trophic and regulatory activities of
CNTF in neurons, oligodendrocytes, muscle cells, bone cells, adipocytes and retinal cells …