[HTML][HTML] Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia
L Legeai-Mallet, C Benoist-Lasselin… - Journal of Biological …, 1998 - ASBMB
Thanatophoric dysplasia (TD) is a lethal skeletal disorder caused by recurrent mutations in
the fibroblast growth factor receptor 3 (FGFR 3) gene. The mitogenic response of fetal TD I
chondrocytes in primary cultures upon stimulation by either FGF 2 or FGF 9 did not
significantly differ from controls. Although the levels of FGFR 3 mRNAs in cultured TD
chondrocytes were similar to controls, an abundant immunoreactive material was observed
at the perinuclear level using an anti-FGFR 3 antibody in TD cells. Transduction signaling …
the fibroblast growth factor receptor 3 (FGFR 3) gene. The mitogenic response of fetal TD I
chondrocytes in primary cultures upon stimulation by either FGF 2 or FGF 9 did not
significantly differ from controls. Although the levels of FGFR 3 mRNAs in cultured TD
chondrocytes were similar to controls, an abundant immunoreactive material was observed
at the perinuclear level using an anti-FGFR 3 antibody in TD cells. Transduction signaling …