Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
WC Mobley, JL Rutkowski, GI Tennekoon… - Molecular Brain …, 1986 - Elsevier
Nerve growth factor (NGF) is a neuronotrophic protein. Its effects on developing peripheral
sensory and sympathetic neurons have been extensively characterized, but it is not clear
whether NGF plays a role during the development of central nervous system neurons. To
address this point, we examined the effect of NGF on the activity of neurotransmitter
enzymes in several brain regions. Intracerebroventricular injections of highly purified mouse
NGF had a marked effect on the activity of choline acetyltransferase (ChAT), a selective …
sensory and sympathetic neurons have been extensively characterized, but it is not clear
whether NGF plays a role during the development of central nervous system neurons. To
address this point, we examined the effect of NGF on the activity of neurotransmitter
enzymes in several brain regions. Intracerebroventricular injections of highly purified mouse
NGF had a marked effect on the activity of choline acetyltransferase (ChAT), a selective …