[HTML][HTML] A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1
H Inomata, Y Nakamura, A Hayakawa, H Takata… - Journal of Biological …, 2003 - ASBMB
Amyloid precursor protein (APP) is the precursor molecule of β-amyloid peptides, the major
components of amyloid plaque in patients with Alzheimer's disease. In this study, we
isolated JIP-1b, a JNK signaling scaffold protein, as a binding protein of APP, and analyzed
the roles of JIP-1b in APP phosphorylation by JNK and the association of kinesin light chain
1 with APP. APP phosphorylation at threonine 668 by JNK was enhanced on the JIP-1b
scaffold in vitro and in cultured cells exogenously expressing APP. APP phosphorylation in …
components of amyloid plaque in patients with Alzheimer's disease. In this study, we
isolated JIP-1b, a JNK signaling scaffold protein, as a binding protein of APP, and analyzed
the roles of JIP-1b in APP phosphorylation by JNK and the association of kinesin light chain
1 with APP. APP phosphorylation at threonine 668 by JNK was enhanced on the JIP-1b
scaffold in vitro and in cultured cells exogenously expressing APP. APP phosphorylation in …