Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease

BC Charrin, F Saudou, S Humbert - Pathologie Biologie, 2005 - Elsevier
Neurodegenerative disorders are a group of inherited or acquired diseases of the nervous
system. They are characterized by the death of specific populations of neurons, leading to
precise clinical features. For most of these diseases, it is not yet understood how specific
neurons degenerate and die. Huntington's disease (HD) is a dominantly inherited
neurodegenerative disease caused by abnormal polyglutamine (polyQ) expansion in a
target protein. HD is characterized by uncontrolled movements (chorea), personality …