Generation of bone marrow and fetal liver chimeric mice
EK Holl - Mouse Models of Allergic Disease: Methods and …, 2013 - Springer
EK Holl
Mouse Models of Allergic Disease: Methods and Protocols, 2013•SpringerThe creation of bone marrow and fetal liver chimeric mice has proven to be a valuable tool in
the field of immunology. Chimeric mice are used to study the contribution of various cell
types of hematopoietic versus non-hematopoietic origin in the course of an immune
response. In this chapter, we describe a detailed method to obtain bone marrow or fetal liver
chimeric mice and assess the efficiency of donor cells to repopulate the hematopoietic
compartment of recipient mice.
the field of immunology. Chimeric mice are used to study the contribution of various cell
types of hematopoietic versus non-hematopoietic origin in the course of an immune
response. In this chapter, we describe a detailed method to obtain bone marrow or fetal liver
chimeric mice and assess the efficiency of donor cells to repopulate the hematopoietic
compartment of recipient mice.
Abstract
The creation of bone marrow and fetal liver chimeric mice has proven to be a valuable tool in the field of immunology. Chimeric mice are used to study the contribution of various cell types of hematopoietic versus non-hematopoietic origin in the course of an immune response. In this chapter, we describe a detailed method to obtain bone marrow or fetal liver chimeric mice and assess the efficiency of donor cells to repopulate the hematopoietic compartment of recipient mice.
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