[HTML][HTML] A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism
T Sakamoto, M Seiki - Journal of biological chemistry, 2010 - ASBMB
Most cells produce ATP in the mitochondria by oxidative phosphorylation. However,
macrophages, which are major players in the innate immune system, use aerobic glycolysis
to produce ATP. HIF-1 (hypoxia-inducible factor-1) regulates expression of glycolysis-related
genes and maintains macrophage glycolytic activity. However, it is unclear how HIF-1
activity is maintained in macrophages during normoxia. In this study, we found that
macrophages lacking membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14), a …
macrophages, which are major players in the innate immune system, use aerobic glycolysis
to produce ATP. HIF-1 (hypoxia-inducible factor-1) regulates expression of glycolysis-related
genes and maintains macrophage glycolytic activity. However, it is unclear how HIF-1
activity is maintained in macrophages during normoxia. In this study, we found that
macrophages lacking membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14), a …