Multiple myeloma is a plasma cell malignancy characterized by the frequent development of
osteolytic bone lesions. The multiple myeloma–induced bone destruction is a result of the
increased activity of osteoclasts that occurs adjacent to multiple myeloma cells. This activity
is accompanied by suppressed osteoblast differentiation and activity, resulting in severely
impaired bone formation and development of devastating osteolytic lesions. Recently the
biologic mechanism involved in the imbalance between osteoclast activation and osteoblast …