The androgen-signaling pathway is important for the growth and progression of prostate
cancer cells. The growth-promoting effects of androgen on prostate cells are mediated
mostly through the androgen receptor (AR). There is increasing evidence that transcription
activation by AR is mediated through interaction with other cofactors. β-Catenin plays a
critical role in embryonic development and tumorigenesis through its effects on E-cadherin-
mediated cell adhesion and Wnt-dependent signal transduction. Here, we demonstrate that …