The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate
K Sato, K Kitakaze, T Nakamura, N Naruse… - Chemical …, 2015 - pubs.rsc.org
K Sato, K Kitakaze, T Nakamura, N Naruse, K Aihara, A Shigenaga, T Inokuma, D Tsuji…
Chemical communications, 2015•pubs.rsc.orgWe describe a novel peptide ligation/desulfurization strategy using a β-mercapto-N-
glycosylated asparagine derivative. The newly developed procedure was successfully
applied to the total chemical synthesis of the GM2 ganglioside activator protein bearing a
monosaccharide on the native glycosylation site.
glycosylated asparagine derivative. The newly developed procedure was successfully
applied to the total chemical synthesis of the GM2 ganglioside activator protein bearing a
monosaccharide on the native glycosylation site.
We describe a novel peptide ligation/desulfurization strategy using a β-mercapto-N-glycosylated asparagine derivative. The newly developed procedure was successfully applied to the total chemical synthesis of the GM2 ganglioside activator protein bearing a monosaccharide on the native glycosylation site.
The Royal Society of Chemistry