Patched 1 conditional null allele in mice
T Ellis, I Smyth, E Riley, S Graham, K Elliot… - Genesis, 2003 - Wiley Online Library
T Ellis, I Smyth, E Riley, S Graham, K Elliot, M Narang, GF Kay, C Wicking, B Wainwright
Genesis, 2003•Wiley Online LibraryThe patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a
central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc
and a number of other pathway members are mutated in some common human cancers.
Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene
leads to developmental defects and an embryonic lethal phenotype. Here we describe a
conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc …
central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc
and a number of other pathway members are mutated in some common human cancers.
Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene
leads to developmental defects and an embryonic lethal phenotype. Here we describe a
conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc …
Abstract
Summary: The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function. genesis 36:158–161, 2003. © 2003 Wiley‐Liss, Inc.
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