[HTML][HTML] Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery
DJ McIlroy, AG Jarnicki, GG Au, N Lott, DW Smith… - Journal of critical …, 2014 - Elsevier
Abstract Introduction Neutrophil extracellular traps (NETs) have not been demonstrated after
trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure
mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We
hypothesized that injury and orthopedic trauma surgery would induce NET production with
mtDNA as a structural component. Methods Neutrophils were isolated 8 trauma patients
requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy …
trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure
mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We
hypothesized that injury and orthopedic trauma surgery would induce NET production with
mtDNA as a structural component. Methods Neutrophils were isolated 8 trauma patients
requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy …