[HTML][HTML] Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach
M Kiebala, J Skalska, C Casulo, PS Brookes… - Experimental …, 2015 - Elsevier
Highlights•B-cell malignancies are a common type of cancer.•We investigated the effect of
auranofin+ BSO on malignant B-cell survival.•AUR interacted synergistically with BSO to
trigger death in malignant B-cell types.•There was less toxicity toward normal B-
cells.•Toxicity is mediated by dual inhibition of TrxR and NF-κB.B-cell malignancies are a
common type of cancer. One approach to cancer therapy is to either increase oxidative
stress or inhibit the stress response systems on which cancer cells rely. In this study, we …
auranofin+ BSO on malignant B-cell survival.•AUR interacted synergistically with BSO to
trigger death in malignant B-cell types.•There was less toxicity toward normal B-
cells.•Toxicity is mediated by dual inhibition of TrxR and NF-κB.B-cell malignancies are a
common type of cancer. One approach to cancer therapy is to either increase oxidative
stress or inhibit the stress response systems on which cancer cells rely. In this study, we …