Complement activation regulates the capacity of proximal tubular epithelial cell to stimulate alloreactive T cell response

K Li, H Patel, CA Farrar, REG Hargreaves… - Journal of the …, 2004 - journals.lww.com
Tissue expression of C3 is an unexpected regulator of the alloimmune response in mouse
kidney transplantation. It is unclear, however, whether a direct or an indirect action of
complement on the host immune response is involved. Also unknown is which of the
complement effector products, cleaved C3, cleaved C5, or C5b-9, is responsible. Proximal
tubular epithelial cells (PTEC) not only constitute a major target of the alloimmune response
but also produce substantial amounts of C3. This study investigated the property of mouse …