High-density lipoproteins play a central role in systemic cholesterol homeostasis by
stimulating the efflux of excess cellular cholesterol and transporting it to the liver for biliary
excretion. HDL has long been touted as the" good cholesterol" because of the strong inverse
correlation of plasma HDL cholesterol levels with coronary heart disease. However, the
disappointing outcomes of recent clinical trials involving therapeutic elevations of HDL
cholesterol have called this moniker into question and revealed our lack of understanding of …