Prion diseases are incurable transmissible neurological disorders. In many natural and
experimental prion diseases, infectious prions can be detected in the lymphoreticular system
(LRS) long before they reach the brain where they cause a fatal rapidly progressive
degeneration. Although major cell types that contribute to prion accumulation have been
identified, the mode of prion dissemination in the LRS remains elusive. Recent evidence of a
remarkably fast splenic prion accumulation after peripheral infection of mice, resulting in …