Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression
KL Taylor, AM Henderson, CCW Hughes - Microvascular research, 2002 - Elsevier
Angiogenesis is essential for normal homeostasis, wound healing, and tumor growth and
involves a switch in endothelial cell (EC) phenotype from quiescence to migration,
proliferation and network formation, and back to quiescence. The notch signaling pathway is
critically involved in cell fate decisions during development, and mice deficient in several
notch/notch ligand genes have vascular phenotypes. Here we show that notch signaling is
activated during EC capillary-like network formation in vitro and that EC express transcripts …
involves a switch in endothelial cell (EC) phenotype from quiescence to migration,
proliferation and network formation, and back to quiescence. The notch signaling pathway is
critically involved in cell fate decisions during development, and mice deficient in several
notch/notch ligand genes have vascular phenotypes. Here we show that notch signaling is
activated during EC capillary-like network formation in vitro and that EC express transcripts …