[HTML][HTML] Interferon-γ–receptor deficiency in an infant with fatal bacille Calmette–Guérin infection

E Jouanguy, F Altare, S Lamhamedi… - … England Journal of …, 1996 - Mass Medical Soc
E Jouanguy, F Altare, S Lamhamedi, P Revy, JF Emile, M Newport, M Levin, S Blanche…
New England Journal of Medicine, 1996Mass Medical Soc
The attenuated strain of Mycobacterium bovis bacille Calmette–Guérin (BCG) is the most
widely used vaccine in the world. In most children, inoculation of live BCG vaccine is
harmless although it occasionally leads to a benign regional adenitis. 1 In rare cases,
however, vaccination causes disseminated BCG infection, which may be lethal. Impaired
immunity of the host is generally thought to be the pathogenic mechanism. Disseminated
BCG infection has been reported in children with inherited immune disorders. Most of these …
The attenuated strain of Mycobacterium bovis bacille Calmette–Guérin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it occasionally leads to a benign regional adenitis.1 In rare cases, however, vaccination causes disseminated BCG infection, which may be lethal. Impaired immunity of the host is generally thought to be the pathogenic mechanism. Disseminated BCG infection has been reported in children with inherited immune disorders. Most of these children had severe combined immunodeficiency, which is characterized by an absence of T cells, and some had chronic granulomatous disease, which is . . .
The New England Journal Of Medicine