Expression profile of peripheral tissue antigen genes in medullary thymic epithelial cells (mTECs) is dependent on mRNA levels of autoimmune regulator (Aire)
EH Oliveira, C Macedo, PB Donate, RS Almeida… - Immunobiology, 2013 - Elsevier
In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune
regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the
later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral
tissue antigen (PTA) gene, which is Aire-dependent, is also deregulated in these mice.
Based in these findings, we hypothesized that the imbalance in PTA gene expression in the
thymus can be associated with slight variations in Aire transcript levels. To test this, we used …
regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the
later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral
tissue antigen (PTA) gene, which is Aire-dependent, is also deregulated in these mice.
Based in these findings, we hypothesized that the imbalance in PTA gene expression in the
thymus can be associated with slight variations in Aire transcript levels. To test this, we used …