Animal models of myasthenia gravis

P Christadoss, M Poussin, C Deng - Clinical immunology, 2000 - Elsevier
Myasthenia gravis (MG) is an antibody-mediated, autoimmune neuromuscular disease.
Animal models of experimental autoimmune myasthenia gravis (EAMG) can be induced in
vertebrates by immunization with Torpedo californica acetylcholine receptors (AChR) in
complete Freund's adjuvant. The MHC class II genes influence the cellular and humoral
immune response to AChR and are involved in the development of clinical EAMG in mice. A
dominant epitope within the AChR α146–162 region activates MHC class II-restricted CD4 …